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Updated: Jul 23, 2025

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
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非リボソーム分子マシンRimKにおける連続ペプチド合成のための静電ラチェット

Jun Ohnuki1, Yasuhiro Arimura2, Tomonori Kono3

  • 1Department of Pure and Applied Physics, Waseda University, Okubo 3-4-1, Shinjuku-Ku, Tokyo 169-8555, Japan.

Journal of the American Chemical Society
|July 15, 2023
PubMed
まとめ

リムK酵素は,ATPで動いている電静的ラッチメカニズムを使用して,グルタミン酸分子を順番に添加します. この分子機械は

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Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
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Rab proteins switch between a cytosolic, GDP-bound inactive state and a membrane-anchored, GTP-bound active state. By themselves, Rabs show slow rates of GDP/GTP exchange and GTP hydrolysis. Thus, Rab proteins are considered...
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