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Updated: Jul 23, 2025

A Rapid In Vivo Bioassay for Developmentally Active Enhancers
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OBOXはマウスのジゴティックゲノム活性化と早期発達を調節する

Shuyan Ji1,2, Fengling Chen1,2, Paula Stein3,4

  • 1Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, New Cornerstone Science Laboratory, School of Life Sciences, Tsinghua University, Beijing, China.

Nature
|July 17, 2023
PubMed
まとめ

OBOXの転写因子はマウスのシゴティックゲノム活性化 (ZGA) と初期の胚発育に不可欠です. OBOXの喪失は発育停止を引き起こし,母からジゴティックへの移行中に遺伝子発現を調節する上で重要な役割を強調します.

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