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Updated: Jul 23, 2025

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers
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Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers

Published on: September 19, 2017

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ヒトのEGFRにおけるメジャーG四重体の構造 腫瘍遺伝子のプロモーターは,独特のスナップバックループを持つユニークな折り畳みトポロジーを採用する

Yushuang Liu1, Jinzhu Li1, Yongqiang Zhang1

  • 1Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu 210009, People's Republic of China.

Journal of the American Chemical Society
|July 17, 2023
PubMed
まとめ

研究者らはEGFR遺伝子プロモーターに新しいG四重体 (G4) 構造を特定した. この独特のEGFR-G4構造は 付近の残留物で 現在の治療法に耐性のある癌の治療に 新たな標的となるのです

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Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

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A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase111:25

A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase1

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