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Updated: Jul 23, 2025

Detection of Heterodimerization of Protein Isoforms Using an in Situ Proximity Ligation Assay
09:18

Detection of Heterodimerization of Protein Isoforms Using an in Situ Proximity Ligation Assay

Published on: October 20, 2018

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プロテイン対プロテインの相互作用の場所での近接標識のための交換可能なDNA触媒

Ashley N Ogorek1, Xu Zhou1, Jeffrey D Martell1,2

  • 1Department of Chemistry, University of Wisconsin─Madison, Madison, Wisconsin 53706, United States.

Journal of the American Chemical Society
|July 18, 2023
PubMed
まとめ

研究者らは,DNAを用いた切り替え可能な近接ラベル (PL) 触媒を開発した. これらの触媒は,分子トリガーがある場合にのみPLを活性化し,タンパク質とタンパク質の相互作用のような特定の細胞の位置に精密なタンパク質ラベルを可能にします.

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