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Updated: Jul 23, 2025

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
07:08

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

Published on: February 2, 2024

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KRAS ((G12D) は,幹細胞再プログラムによる白血球性腺癌を駆動する.

Nicholas H Juul1,2, Jung-Ki Yoon1,2, Marina C Martinez2

  • 1Division of Pulmonary, Allergy and Critical Care, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Nature
|July 19, 2023
PubMed
まとめ

研究者らは 分化したAT1細胞が 肺腺がんの幹細胞に 再プログラムできることが分かり 癌の起源に関する以前の理解に 挑戦しました この発見は 発症細胞が癌の発生に 果たす重要な役割を強調しています

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The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
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Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
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