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関連する概念動画

Translesion DNA Polymerases02:10

Translesion DNA Polymerases

10.0K
Translesion (TLS) polymerases rescue stalled DNA polymerases at sites of damaged bases by replacing the replicative polymerase and installing a nucleotide across the damaged site. Doing so, TLS allows additional time for the cell to repair the damage before resuming regular DNA replication.
TLS polymerases are found in all three domains of life - archaea, bacteria, and eukaryotes. Of the different classes of TLS polymerases, members of the Y family are fitted with specialized structures that...
10.0K
The Replisome03:01

The Replisome

33.9K
DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with...
33.9K
DNA Bacteriophages01:26

DNA Bacteriophages

52
Bacteriophages, or phages, are viruses that specifically infect bacteria, utilizing their genetic material to hijack host cellular machinery for replication. DNA bacteriophages employ single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA) genomes. These phages exhibit diverse replication strategies and host interactions, influencing their ecological roles and applications in biotechnology and medicine.ssDNA BacteriophagesssDNA phages, with their small genomes, utilize unique strategies to...
52
Chromosome Structure02:40

Chromosome Structure

22.9K
A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
22.9K
Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

6.0K
Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
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Replication in Prokaryotes02:35

Replication in Prokaryotes

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Overview
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関連する実験動画

Updated: Jul 22, 2025

In Vitro Directed Evolution of a Restriction Endonuclease with More Stringent Specificity
09:16

In Vitro Directed Evolution of a Restriction Endonuclease with More Stringent Specificity

Published on: March 25, 2020

7.3K

エナチオセレクティブ・セルフ・レプリケーター

Shuo Yang1,2,3, Yannick Geiger2, Marc Geerts2

  • 1State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.

Journal of the American Chemical Society
|July 24, 2023
PubMed
まとめ
この要約は機械生成です。

生命の起源に不可欠な自己複製分子に影響を与えます 研究者達は 生命の出現に関する研究を進めるため,キラル前駆者を分類する 酵素選択的自己複製剤を開発した.

さらに関連する動画

Chemical Triphosphorylation of Oligonucleotides
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Chemical Triphosphorylation of Oligonucleotides

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Direct Observation of Enzymes Replicating DNA Using a Single-molecule DNA Stretching Assay
17:03

Direct Observation of Enzymes Replicating DNA Using a Single-molecule DNA Stretching Assay

Published on: March 23, 2010

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関連する実験動画

Last Updated: Jul 22, 2025

In Vitro Directed Evolution of a Restriction Endonuclease with More Stringent Specificity
09:16

In Vitro Directed Evolution of a Restriction Endonuclease with More Stringent Specificity

Published on: March 25, 2020

7.3K
Chemical Triphosphorylation of Oligonucleotides
13:19

Chemical Triphosphorylation of Oligonucleotides

Published on: June 2, 2022

3.4K
Direct Observation of Enzymes Replicating DNA Using a Single-molecule DNA Stretching Assay
17:03

Direct Observation of Enzymes Replicating DNA Using a Single-molecule DNA Stretching Assay

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18.8K

科学分野:

  • 化学について
  • 生命 の 起源 に 関する 研究
  • 超分子化学

背景:

  • 自己複製する分子は 生命の起源を理解する鍵です
  • 生命に不可欠ですが 初期の自己複製におけるその役割は 十分に研究されていません

研究 の 目的:

  • 自己複製分子に対するヒラリティの影響を調査する.
  • 生命の出現を研究するための自己複製剤を開発する.

主な方法:

  • 合成した自己複製装置
  • 評価されたエナチオセレクティブ性と前駆体組み込み.
  • エナチオ選択性に対する構造的影響を研究した.

主要な成果:

  • 自発的に自己複製する新しい自己複製器を開発し,自発的なエナチオ選択性を示した.
  • エナティオプア・レプリケータにキラル前駆者を効率的に分類した.
  • 特定された構造的特徴 (リングサイズ) が,エナンチオセレクティブ性を支配する.

結論:

  • エナチオセレクティブの自己複製物質は,エナチオ純粋な物質から発生し,成長することができます.
  • これらのレプリケーターは,キラリティに基づいてラセミック前駆者を分類することができます.
  • 構造的制約は自己複製体の反選択性において重要な役割を果たし,生命の合成を進める.