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Updated: Jul 22, 2025

Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
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多成分酸化ニトリルチアゾリジネーション反応 N端末二甲基化の選択的改変 翻訳後の改変

Benjamin Emenike1, Julia Donovan1, Monika Raj1

  • 1Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.

Journal of the American Chemical Society
|July 24, 2023
PubMed
まとめ

新しい方法である酸化ニトリルチアゾリジネーション (OxNiTha) を開発し,α-N末端二甲基化 (Nme2) 後の変異を検出しました. この技術は,タンパク質とペプチドのNme2部位を選択的に修正し,細胞溶解物からそれらの濃縮を可能にします.

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