Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Molecules with Multiple Chiral Centers02:25

Molecules with Multiple Chiral Centers

11.8K
Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
11.8K
SN2 Reaction: Stereochemistry02:23

SN2 Reaction: Stereochemistry

9.7K
In an SN2 reaction, the nucleophilic attack on the substrate and departure of the leaving group occurs simultaneously through a transition state. As the nucleophile approaches the substrate from the back-side, the configuration of the substrate carbon changes from tetrahedral to trigonal bipyramidal and then back to tetrahedral, leading to an inversion in the configuration of the product.
If the substrate is an achiral molecule at the α-carbon, the inversion of configuration is not...
9.7K
Prochirality02:05

Prochirality

3.8K
The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
3.8K
SN1 Reaction: Stereochemistry02:15

SN1 Reaction: Stereochemistry

8.7K
This lesson provides an in-depth discussion of the stereochemical outcomes in an SN1 reaction.
In the first step of an SN1 reaction, the bond between the electrophilic carbon and the leaving group ionizes to generate the carbocation intermediate. The second step of the mechanism is the nucleophilic attack.
In the formed carbocation, the positively charged carbon is sp2 hybridized with a trigonal planar geometry. As all the three substituents lie on the same plane, a plane of symmetry for the...
8.7K
Chirality02:25

Chirality

24.4K
Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
24.4K
Stereoisomerism of Cyclic Compounds02:33

Stereoisomerism of Cyclic Compounds

9.0K
In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...
9.0K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Molecular Recognition and Spatial Confinement in CD-MOF Drive Tandem Photocatalytic CO<sub>2</sub> Reduction and Alcohol Oxidation.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Simulation of homogeneous electrochemical proton-coupled electron transfer using the hybrid-bath hierarchical equations of motion.

The Journal of chemical physics·2026
Same author

Dual-Stimulus Chiroptical Switch of Tetrastable [3]Rotaxanes.

Organic letters·2026
Same author

Electrospinning Achieving Supramolecular Cyclodextrin-Polyaniline Layered Fabric for Expanding Conductive Performance of Flexible Electrode.

Macromolecular rapid communications·2026
Same author

Cucurbit[8]Uril Achieved Single-Molecule Chiral Transfer to Supramolecular Circularly Polarized Luminescence.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Recent Advances in Artificial Intelligence in Organic Electronic Research.

Advanced materials (Deerfield Beach, Fla.)·2026

関連する実験動画

Updated: Jul 22, 2025

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
07:36

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy

Published on: November 9, 2019

8.0K

ユニモレキュラー・キラル・ステップインバーション・マシン

Yonghui Sun1, Lijuan Liu1, Linnan Jiang1

  • 1College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China.

Journal of the American Chemical Society
|July 24, 2023
PubMed
まとめ

この研究は,リバーシブルキラル・インバーションをリドックス刺激を用いて達成する新しい単分子キラル・ステップインバーション分子マシン (SIMM) を提示する. この分子機械は 刺激に反応する高度なキラルシステムを 開発する新たな経路を提供します

さらに関連する動画

Probing the Structure and Dynamics of Interfacial Water with Scanning Tunneling Microscopy and Spectroscopy
10:28

Probing the Structure and Dynamics of Interfacial Water with Scanning Tunneling Microscopy and Spectroscopy

Published on: May 27, 2018

8.8K
Direct Imaging of Laser-driven Ultrafast Molecular Rotation
10:52

Direct Imaging of Laser-driven Ultrafast Molecular Rotation

Published on: February 4, 2017

9.8K

関連する実験動画

Last Updated: Jul 22, 2025

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
07:36

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy

Published on: November 9, 2019

8.0K
Probing the Structure and Dynamics of Interfacial Water with Scanning Tunneling Microscopy and Spectroscopy
10:28

Probing the Structure and Dynamics of Interfacial Water with Scanning Tunneling Microscopy and Spectroscopy

Published on: May 27, 2018

8.8K
Direct Imaging of Laser-driven Ultrafast Molecular Rotation
10:52

Direct Imaging of Laser-driven Ultrafast Molecular Rotation

Published on: February 4, 2017

9.8K

科学分野:

  • 分子機械
  • 超分子化学
  • キラリティ

背景:

  • 光,電気,温度に反応する 知的分子機械は 極めて興味深いものです
  • 刺激に反応する分子機械は 化学,材料科学,生物学における進歩にとって 極めて重要です

研究 の 目的:

  • 単分子キラル・ステップインバーション分子機械 (SIMM) の構築と調査.
  • CD信号のリバーシブルスイッチングを証明する.

主な方法:

  • ディブロモピラー[5]アレンとテトラチアフルバレン (TTF) デリバティブの結合によるSIMMの合成.
  • 電気化学実験で レドックス性質を研究する
  • クイラルスイッチングをモニターするための円形二重化 (CD) スペクトロスコーピー.

主要な成果:

  • SIMMは2電子のリドックスポテンシャルによって誘発されたキラルステップインバーションを示します.
  • レドックス処理は,SIMMのCD信号の可逆的なスイッチングを誘導する.
  • 化学的酸化剤と還元剤を用いて,キラル逆転を達成し,逆転させました.

結論:

  • この研究は,酸化還元刺激に反応する単分子キラルステップインバーションを示しています.
  • 開発されたSIMMは,刺激反応性キラリティのための新しいプラットフォームを提供します.
  • この研究は,高度な分子機械を設計するための新しい道を開きます.