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関連する概念動画

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Pigmentation01:19

Pigmentation

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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
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Cells of the Epidermis01:24

Cells of the Epidermis

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The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
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Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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A 3D Organotypic Melanoma Spheroid Skin Model
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A 3D Organotypic Melanoma Spheroid Skin Model

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皮膚メラノーマ

Georgina V Long1, Susan M Swetter2, Alexander M Menzies3

  • 1Melanoma Institute Australia, Sydney, NSW, Australia; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia; Department of Medical Oncology, Royal North Shore Hospital, Sydney, NSW, Australia; Department of Medical Oncology, Mater Hospital, Sydney, NSW, Australia.

Lancet (London, England)
|July 27, 2023
PubMed
まとめ
この要約は機械生成です。

皮膚がんである皮膚メラノーマは 紫外線に曝されていることが多いのです 免疫療法を含む先進的な治療法により メラノーマ患者の生存率が著しく改善されました

さらに関連する動画

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

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関連する実験動画

Last Updated: Jul 21, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

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科学分野:

  • 皮膚科
  • 腫瘍学

背景:

  • 皮膚メラノーマの発生率は,特に肌が明るい人群では増加しています.
  • 紫外線曝露は主要な危険因子ですが,一部のメラノーマサブタイプは紫外線とは無関係です.
  • 診断は,原発性腫瘍の臨床的および組織病理学的評価に依存し,それは色素化またはアメラノティックである可能性があります.

研究 の 目的:

  • 皮膚メラノーマの診断と管理について概要を述べる.
  • メラノーマの全身治療の 進歩を強調するために
  • 複合的な症例における多学科治療の重要性を強調する.

主な方法:

  • 主発性メラノーマの臨床的および組織病理学的診断基準のレビュー
  • 広範な切除,免疫療法,標的療法,放射線療法を含む治療方法の説明
  • 進行および転移性メラノーマに対する全身性薬物療法に関する議論

主要な成果:

  • 広い切除は局所性メラノーマの主要な治療法であり,腫瘍の厚さに基づく範囲です.
  • システム療法,特に免疫チェックポイント阻害剤は 2011年以降 進行メラノーマの生存率を劇的に改善しています
  • 進行性メラノーマの治療には 特に脳転移の治療には 複雑で多分野的なアプローチが必要です

結論:

  • 早期診断と手術や補助療法を含む適切な治療は メラノーマの治療に不可欠です
  • 進行性メラノーマの治療において システム薬療法は大きな進歩であり 患者の治療結果を大幅に改善しています
  • 複合的なメラノーマの 管理を最適化するために 統合された多学科的ケアが不可欠です