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Updated: Jul 21, 2025
08:49
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
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皮膚メラノーマ
Georgina V Long1, Susan M Swetter2, Alexander M Menzies3
1Melanoma Institute Australia, Sydney, NSW, Australia; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia; Department of Medical Oncology, Royal North Shore Hospital, Sydney, NSW, Australia; Department of Medical Oncology, Mater Hospital, Sydney, NSW, Australia.
Lancet (London, England)
|July 27, 2023
まとめ
皮膚がんである皮膚メラノーマは 紫外線に曝されていることが多いのです 免疫療法を含む先進的な治療法により メラノーマ患者の生存率が著しく改善されました
科学分野:
- 皮膚科
- 腫瘍学
背景:
- 皮膚メラノーマの発生率は,特に肌が明るい人群では増加しています.
- 紫外線曝露は主要な危険因子ですが,一部のメラノーマサブタイプは紫外線とは無関係です.
- 診断は,原発性腫瘍の臨床的および組織病理学的評価に依存し,それは色素化またはアメラノティックである可能性があります.
研究 の 目的:
- 皮膚メラノーマの診断と管理について概要を述べる.
- メラノーマの全身治療の 進歩を強調するために
- 複合的な症例における多学科治療の重要性を強調する.
主な方法:
- 主発性メラノーマの臨床的および組織病理学的診断基準のレビュー
- 広範な切除,免疫療法,標的療法,放射線療法を含む治療方法の説明
- 進行および転移性メラノーマに対する全身性薬物療法に関する議論
主要な成果:
- 広い切除は局所性メラノーマの主要な治療法であり,腫瘍の厚さに基づく範囲です.
- システム療法,特に免疫チェックポイント阻害剤は 2011年以降 進行メラノーマの生存率を劇的に改善しています
- 進行性メラノーマの治療には 特に脳転移の治療には 複雑で多分野的なアプローチが必要です
結論:
- 早期診断と手術や補助療法を含む適切な治療は メラノーマの治療に不可欠です
- 進行性メラノーマの治療において システム薬療法は大きな進歩であり 患者の治療結果を大幅に改善しています
- 複合的なメラノーマの 管理を最適化するために 統合された多学科的ケアが不可欠です
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