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Updated: Jul 20, 2025

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ADAM10による基板の膜近接タンパク質分解の構造的基礎

Colin H Lipper1, Emily D Egan1, Khal-Hentz Gabriel2

  • 1Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.

Cell
|July 29, 2023
PubMed
まとめ

ADAM10タンパク質の活動は,その活性部位を膜近接裂部位に配置するテトラスパニンTspan15によって調節される. このメカニズムは哺乳類の発達とAPP処理に不可欠であり,病気の調節戦略を提供します.

キーワード:
APP についてアルツハイマー病ノッチ・シグナルアルファ・セクレターゼエクトドメインの流出メタロプロテアゼテトラスパニン

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