関連する実験動画

Updated: Jul 20, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

8.9K

バイアス細胞内アゴニストによる保存されたクラスBのGPCR活性化

Li-Hua Zhao1,2, Qian He3,4, Qingning Yuan3

  • 1State Key Laboratory of Drug Research, Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. zhaolihuawendy@simm.ac.cn.

Nature
|July 31, 2023
PubMed
まとめ

研究者らは,副甲状腺ホルモン1受容体 (PTH1R) を標的とする小分子薬の新しい結合部位を発見した. この発見は,クラスBのGタンパク質結合受容体 (GPCR) に対して口服可能な薬剤につながる可能性がある.

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