次世代のプロバイオティクスの開発のためのシナジーと酸素適応
Muhammad Tanweer Khan1,2, Chinmay Dwibedi1,3, Daniel Sundh4
1Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Nature
|August 2, 2023
まとめ
次の世代のプロバイオティクスは 今や 腸内無酸素細菌である Faecalibacterium prausnitzii から開発できます この突破は これらの微生物を酸素に耐えるように 適応させることで 新しい腸内療法を可能にします
科学分野:
- 微生物学
- 胃腸内科
- プロバイオティクス
背景:
- 人間の腸内微生物群は 健康や病気に大きな影響を与えます
- 排気性細菌は 腸の健康に不可欠ですが プロバイオティクスとして作るのは難しいのです
- 次世代のプロバイオティクスは 腸内微生物群を調節して 健康状態を改善することを目的としています
研究 の 目的:
- 完全に無酸素の細菌から 次世代のプロバイオティクスを生産する方法を開発する.
- Faecalibacterium prausnitziiとDesulfovibrio pigerの共分離と交配を調査する
- 有益な性質を損なわずに酸素耐性を高めるために F. prausnitzii を適応させる.
主な方法:
- F.prausnitziiとDesulfovibrio pigerの同隔離
- F.prausnitziiが酸素に耐えるように適応する.
- 臨床試験によるマウスとヒトにおける共生製品の耐性および検出率の評価 (NCT03728868).
主要な成果:
- F.prausnitziiとD.pigerとの交配が成功し,成長とバチレートの生成が促進された.
- プロバイオティクスの製造に適した酸素耐性F.prausnitzii菌株を開発した.
- 概念実証研究では,共生製品はマウスとヒトでよく耐受され,ヒトの腸内でも検出可能であることが確認されました.
結論:
- 新しい技術により 完全に無酸素の腸内細菌から 次世代のプロバイオティクスを 生成できます
- このアプローチは,プロバイオティクスの発達のための酸素感受性の制限を克服します.
- この技術は他の無酸素菌株を 効果的な次世代プロバイオティクスに発展させる可能性を秘めています
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