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Updated: Jul 20, 2025

High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds
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High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds

Published on: January 23, 2018

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微生物-宿主-同酵素分析により,微生物DPP4が潜在的な抗糖尿病標的であることが明らかになった

Kai Wang1,2, Zhiwei Zhang1,2, Jing Hang1,3,4

  • 1Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University, Beijing, China.

Science (New York, N.Y.)
|August 3, 2023
PubMed
まとめ

腸内微生物は,グルコース代謝を乱す酵素であるディペプチジルペプチダゼ4 (DPP4) を生成する. 新しい阻害剤であるダウリスリン-d4 (Dau-d4) は,選択的に微生物のDPP4を標的とし,マウスのグルコース耐性を改善します.

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