関連する実験動画

Updated: Jul 20, 2025

In Vitro Characterization of the Electrophysiological Properties of Colonic Afferent Fibers in Rats
08:19

In Vitro Characterization of the Electrophysiological Properties of Colonic Afferent Fibers in Rats

Published on: September 27, 2017

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ディスタル大腸からの生理学的および病理学的メカノセンセーションを媒介するDRGアフェレンツ

Rachel L Wolfson1, Amira Abdelaziz2, Genelle Rankin2

  • 1Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA; Division of Gastroenterology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.

Cell
|August 4, 2023
PubMed
まとめ

研究者らは,大腸の異なる背筋の根のギャングリア (DRG) ニューロン集団を特定した. 特定の高度メカニカセンサリー (HTMR) Aδ集団は,大腸の膨張と炎症に対する反応を媒介し,治療目標を提供します.

キーワード:
大腸背筋の根のギャングリア炎症性痛み機械感知感覚生理学

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Sensory Functions of the Skin

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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
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Major Somatic Sensory Pathways

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The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
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Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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