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Updated: Jul 19, 2025

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
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Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides

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アミノキノリン誘導C-H機能化における銅 (II) と銅 (III) σ-アリル中間体の特徴と反応性

Isaac M Blythe1, Jingtong Xu2, Joaquin S Fernandez Odell2

  • 1Department of Chemistry, University of Michigan, 930 N. University Avenue, Ann Arbor, Michigan 48109, United States.

Journal of the American Chemical Society
|August 8, 2023
PubMed
まとめ

この研究は,C−H機能化反応における主要な銅 (II) と銅 (III) の中間物質を特定する. これらの中間物質は,新しい触媒経路を通じて効率的なC-CとC-NO2結合形成を可能にします.

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Treating arylamines with nitrous acid gives aryldiazonium salts that are effective substrates in nucleophilic aromatic substitution reactions. The diazonio group in these salts can be easily displaced by different nucleophiles, yielding a wide variety of substituted benzenes. The leaving group departs as nitrogen gas, and this easy elimination is the driving force for the substitution reaction.
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