関連する実験動画

Updated: Jul 19, 2025

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
09:01

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

428

癌の免疫回避のための膜関連MHC-I抑制軸

Xufeng Chen1, Qiao Lu1, Hua Zhou2

  • 1Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA; The Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, USA.

Cell
|August 9, 2023
PubMed
まとめ

研究者らは,表面タンパク質SUSD6,TMEM127,およびWWP2を含む癌の免疫回避の新しいメカニズムを発見し,これは主要な組織適合性複合体のクラスIプレゼンテーションを阻害する. この軸をターゲットにすることで,がんの免疫療法への反応が改善される可能性があります.

キーワード:
MHC-ISUSD6 についてT細胞TMEM127 についてWWP2 について抗原の表示癌について免疫回避リンソーム分解ユビキチネーション

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