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Updated: Jul 19, 2025

Analysis of Termination of Transcription Using BrUTP-strand-specific Transcription Run-on TRO Approach
12:12

Analysis of Termination of Transcription Using BrUTP-strand-specific Transcription Run-on TRO Approach

Published on: March 12, 2017

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Rループ依存のプロモーター近接結末はゲノム安定性を確保する.

Congling Xu1, Chengyu Li2, Jiwei Chen1

  • 1Fudan University Shanghai Cancer Center, Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Medical Epigenetics, Shanghai Key Laboratory of Radiation Oncology, Human Phenome Institute, Fudan University, Shanghai, China.

Nature
|August 9, 2023
PubMed
まとめ

単一鎖DNA (SOSS) とインテグレーターPP2A (INTAC) 複合体のセンサーは,ゲノムの安定性を維持するために転写を調節します. この複合体はRループの蓄積を防止し,DNAの損傷を防止し,細胞の機能を確保するために不可欠です.

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