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TRIM5αはポックスウイルスを抑制し,CypAとウイルスタンパク質C6によって反抗する

Yiqi Zhao1,2, Yongxu Lu1,2, Samuel Richardson3

  • 1Department of Pathology, University of Cambridge, Cambridge, UK.

Nature
|August 9, 2023
PubMed
まとめ

人間のTRIM5α (トリパートイトモチーフタンパク質5α) は,オートポックスウイルスのカプシドタンパク質L3に結合することによって,それを制限する. ウイルスのタンパク質C6とサイクロフィリンAは これに対抗しますが,CsAのような薬はそれらを阻害し,抗ウイルス性を提供します.

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