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Updated: Jul 19, 2025

Fully Processed Recombinant KRAS4b: Isolating and Characterizing the Farnesylated and Methylated Protein
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変異KRASの活性状態をターゲットにするための細胞チャペロンの化学改造

Christopher J Schulze1, Kyle J Seamon1, Yulei Zhao2

  • 1Department of Biology, Revolution Medicines, Inc., Redwood City, CA 94063, USA.

Science (New York, N.Y.)
|August 17, 2023
PubMed
まとめ

研究者はKRAS G12Cという がんを誘発する共通変異を標的とした 新しい小分子を開発しました この薬はサイクロフィリンAに新しい結合部位を作り,がんの成長を効果的に阻害し,モデルでは腫瘍の逆行を引き起こします.

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