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Updated: Jul 19, 2025

Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method
08:53

Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method

Published on: May 2, 2025

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In silico タンパク質の相互作用スクリーニングは,複製開始における DONSON の役割を明らかにした.

Yang Lim1, Lukas Tamayo-Orrego2, Ernst Schmid1

  • 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, MA 02115, USA.

Science (New York, N.Y.)
|August 17, 2023
PubMed
まとめ

DONSONタンパク質は,CDC45-MCM2-7-GINS (CMG) ヘリコアスを組み立てることによって,真核細胞のDNA複製の開始に不可欠です. ドンソンの変異は 小脳症を引き起こし 人間の発達における 小脳症の役割を強調しています

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