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Updated: Jul 18, 2025

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
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リンパ系スフィンゴシン-1-フォスファートの異常信号はリンパ系機能障害と組織炎症を悪化させる

Dongeon Kim1,2, Wen Tian1,2, Timothy Ting-Hsuan Wu2,3

  • 1VA Palo Alto Health Care System, Palo Alto, CA (D.K., W.T., M.X., R.V., J.L.C., S.G., S.L., Y.Z., T.G., E.C.S., E.B., J.P., X.J., M.R.N.).

Circulation
|August 23, 2023
PubMed
まとめ

リンパ内皮細胞 (LEC) のスフィンゴシン-1- フォスファート (S1P) 信号伝達が低下すると,細胞粘着とT細胞活性化によりリンパ腫が悪化します. P-セレクチン阻害剤は,この状態の治療に希望を示しています.

キーワード:
P-セレクチンTリンパ球リンパ内皮細胞リンパ腫スフィンゴシン-1-リン酸受容体 1

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