野生のジャガイモの免疫受容体の原点における機能的多様化

Yerisf C Torres Ascurra¹, Lisha Zhang², AmirAli Toghani³

¹Plant Breeding, Wageningen University and Research, 6708 PB Wageningen, Netherlands.

Science (New York, N.Y.)

|August 24, 2023

まとめ

研究者らは,ポテトのPep-13受容体 (PERU) と呼ばれるパターン認識受容体 (PRR) を特定し,Phytophthoraに対する免疫力を高めました. 野生のジャガイモの多様化はアンデス山脈で進化する免疫受容体アレルを示しています

科学分野:

植物免疫
分子植物病理学
進化生物学

背景:

植物免疫受容体は,パターン認識受容体 (PRR) と細胞内免疫受容体を含むが,微生物の防御に不可欠である.
これらの受容体ファミリーの共進化は速いが,PRRの進化経路はほとんど未知のままである.

研究の目的:

Phytophthoraに対する植物の防御に関与する新しいジャガイモのPRRを分離し,特徴づけること.
野生のジャガイモの集団におけるこのPRRの進化的多様化を調査する.

主な方法:

ポテトからPep-13受容体 (PERU) の分離と特徴づけ.
ペルウがペプ-13ペプチドと結合することを確認する生化学分析
中央アンデスから野生のSolanum集団のPERUアレル多様化の分析.

主要な成果:

ポテトの表面受容体PERUを分離し,ルシンに富んだリピート受容体キナーゼとして特定した.
PERUは,Phytophthora種から保存されたPep-13ペプチドを直接結合する真のPRRとして機能します.
PERUの結合とPhytophthora infestansに対する免疫が強化された.
PERUのリガンド結合特異性の多様化は,野生の結節性Solanum群で観察された.

結論:

PERUは,ポテトの重要な細胞表面免疫受容体であり,Pep-13認識を通じてPhytophthoraに対する耐性を授与する.
この研究は,野生のジャガイモの親戚におけるPRRアレルの進化を明らかにし,病原体の多様性への適応におけるその役割を強調しています.
この多様化により,新しいリガンドの変種が認識され,進行中の植物病原体の共進化に寄与します.

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