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Updated: Jul 18, 2025

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis
11:50

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis

Published on: April 10, 2012

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トロンボポエチン-MPL受容体複合体の構造は,バイアス血液形成の青写真である

Naotaka Tsutsumi1, Zahra Masoumi2, Sophie C James2

  • 1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan.

Cell
|August 26, 2023
PubMed
まとめ

トロンボポエチン (TPO) の構造は,その受容体を活性化して,改変されたTPOの変種を生成することを示しています. これらの変種は血小板の産生を選択的に刺激し,血液形成幹細胞を保存し,血液学の研究と移植を助けます.

キーワード:
JAK-STAT についてTPOR についてc-MPLクリオ・エムヘマトポエシスリガンド工学mTOR についてシグナリング構造トロンボポエチン

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