大手胸部手術 (COP- AF) を受けた患者における外科手術後の心房細動および心筋損傷に対するコルキシンの影響:国際ランダム化試験
PubMedで要約を見る
まとめ
この要約は機械生成です。コルキシンは,非心臓手術 (MINS) の後の術後の心房細動または心筋損傷を有意に減少させなかった. しかし,胸部手術を受けた患者では非感染性下痢のリスクが増加しました.
科学分野
- 心臓病科
- 薬理学について
- 手術 の 結果
背景
- 炎症性バイオマーカーは,非心臓手術 (MINS) の後の手術前動脈動および心筋損傷のリスクの増加と相関しています.
- 抗炎症剤であるコルキシンは,これらの外科的合併症を緩和する可能性について調査されました.
研究 の 目的
- 臨床的に重要な手術前動脈動およびMINSの発生率を低減する口服コルキシンの有効性を評価する.
- セプシス,感染,非感染性下痢のリスクを含むコルキシンの安全性に関する評価を行う.
主な方法
- 55歳以上の3209人の心臓外科手術を受けた患者によるランダム化,ダブルブラインド,プラセボ対照試験 (COP- AF).
- 患者は手術前10日間,口服用コルキシン (0. 5 mg,毎日2回) またはプラセボを投与された.
- コプライマリーアウトカムには,臨床的に重要な手術後の心房細動と14日以内のMINSがあり,安全性アウトカムには,感染と下痢が含まれていた.
主要な成果
- 臨床的に重要な心房細動は,コルキシン群の6. 4%とプラセボ群の7. 5%で発生した (HR 0. 85; p=0. 22).
- MINSは,コルキシン群の18. 3%,プラセボ群の20. 3%で発生した (HR 0. 89; p=0. 16).
- コルキシン群では非感染性下痢の頻度はプラセボ群と比較して有意に高かった (8. 3%).
結論
- コルキシン投与は,心臓外の大規模な胸部手術を受けた患者で,手術後の心房細動またはMINSの発生率を有意に低下させなかった.
- コルヒシンの使用は,非感染性下痢の発生率,主に良性の副作用と関連していました.
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