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Updated: Jul 17, 2025

Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model
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細胞内tPA-PAI-1相互作用は,肝細胞におけるVLDLの集合を決定する

Wen Dai1, Heng Zhang1, Hayley Lund2

  • 1Versiti Blood Research Institute, Milwaukee, WI 53226, USA.

Science (New York, N.Y.)
|August 31, 2023
PubMed
まとめ

組織プラズミノゲン活性化剤 (tPA) は,肝細胞におけるMTPとの相互作用を阻害することによって,アテロゲンアポリプロテインB (apoB) を減少させます. プラズミノゲン活性化阻害剤1 (PAI-1) は,この効果を逆転させ,VLDLの構成とコレステロールレベルに影響を与えます.

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