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Updated: Jul 17, 2025

Author Spotlight: Advancing Protein Engineering – Harnessing Evolution Through PRANCE and Lab Automation
05:08

Author Spotlight: Advancing Protein Engineering – Harnessing Evolution Through PRANCE and Lab Automation

Published on: January 12, 2024

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菌糸体 による 進化 と タンパク質 工学 は,コンパクト で 効率 的 な プライム エディター を 生み出す

Jordan L Doman1, Smriti Pandey1, Monica E Neugebauer1

  • 1Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA.

Cell
|September 1, 2023
PubMed
まとめ

研究者は精密なゲノム編集のために より小さく効率的なプライム編集ツールを設計した. これらの高度なプライムエディタは 細胞内の改善された治療的編集を示し,より長いDNA挿入を in vivoで可能にします.

キーワード:
CRISPR-Cas9について誘導された進化ゲノム編集ガイドRNAペグRNAs菌糸体による継続的進化プライム編集タンパク質工学

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