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関連する概念動画

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

9
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
9
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

19
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
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Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

8
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
8
Nephrons01:10

Nephrons

2.7K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
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Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

29
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
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Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
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乳児性腎症候群

Marina Vivarelli1, Keisha Gibson2, Aditi Sinha3

  • 1Division of Nephrology, Laboratory of Nephrology, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.

Lancet (London, England)
|September 2, 2023
PubMed
まとめ

子供のイディオパシー腎症候群は,コルチコステロイドで治療されます. ステロイド耐性症例では,代替免疫抑制薬が必要となり,それに対応した治療戦略の必要性を強調する.

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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
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科学分野:

  • 小児腎臓科
  • グロメルール疾患
  • 免疫抑制

背景:

  • Idiopathic nephrotic syndromeは,子供期における最も一般的な球疾患である.
  • コルチコステロイドは主な治療法であり,ステロイド反応は主要な予後指標である.
  • ステロイド感受性腎症候群は初期治療に反応し,ステロイド耐性型はさらなる治療を必要とします.

研究 の 目的:

  • 腎不全症候群の病理学に関する現在の理解をレビューする.
  • ステロイド感受性,ステロイド耐性,多剤耐性腎症候群の治療戦略を概説する.
  • 合併症や副作用のモニタリングと管理を強調する

主な方法:

  • イディオパシー腎症候群に関する既存の文献のレビュー.
  • 治療反応と予後要因の分析
  • 免疫媒介性および単一性の起源を含む病理生理学の議論

主要な成果:

  • ほとんどの子供は経口ステロイドで寛解 (ステロイド感受性) を得ます.
  • ステロイド耐性腎症候群はしばしばカルシヌーリンの阻害剤に反応するが,いくつかの症例は多剤耐性である.
  • 単一性の原因はステロイド耐性患者の3分の"を占めています

結論:

  • 急性合併症を予防し,長期的な副作用を最小限に抑えるために,腎臓症候群の管理には注意深い監視が必要です.
  • ステロイドを節約する薬は,再発または抵抗性の症例の管理に不可欠です.
  • 基礎的な病理生理学を理解することは,結果を改善するための鍵であり,一部の患者は成人期に病気を経験します.