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Updated: May 4, 2026

Caspase-3 Activity in the Rat Amygdala Measured by Spectrofluorometry After Myocardial Infarction
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"SERCA2に結合するフォスフォディエステラーゼ3Aの障害は,SERCA2の活性を増やし,慢性心不全のマウスの死亡率を低下させる"という記事に関する手紙に対するAronsen等による回答

Jan Magnus Aronsen1,2, Jonas Skogestad1,2, Ingrid Albert3

  • 1Department of Molecular Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Norway (J.M.A., J.S., A.O.M.).

Circulation
|September 5, 2023
PubMed
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No abstract available in PubMed .

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The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
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