関連する実験動画

Updated: Jul 17, 2025

Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay
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Covalent Fragment Screening Using the Quantitative Irreversible Tethering Assay

Published on: February 28, 2025

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非選択的断片からの14-3-3σ/ERαタンパク質相互作用の共性小分子安定剤の構造ベースの最適化

Markella Konstantinidou1, Emira J Visser2, Edmee Vandenboorn2

  • 1Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC), University of California, San Francisco, California 94143, United States.

Journal of the American Chemical Society
|September 7, 2023
PubMed
まとめ

研究者は,特に14-3-3σ/ERα複合体を標的とした,タンパク質とタンパク質の相互作用 (PPI) を安定させるための選択的分子接着剤を開発した. この構造によるアプローチは 薬剤発見の効能と選択性を最適化します

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