Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Crossing Over01:30

Crossing Over

4.5K
Crossing over is the exchange of genetic information between homologous chromosomes during prophase I of meiosis I. Genetic recombination gives rise to allelic diversity in the newly formed daughter cells. In humans, crossing over produces genetically distinct haploid egg and sperm cells that undergo fertilization to produce unique offspring. Before cell division starts, the germ cell’s chromosome(s) undergo duplication in the S phase of the cell cycle. As the cells enter prophase I,...
4.5K
Polytene Chromosomes02:04

Polytene Chromosomes

10.1K
Polytene chromosomes are giant interphase chromosomes with several DNA strands placed side by side. They were discovered in the year 1881 by Balbiani in salivary glands, intestine, muscles, malpighian tubules, and hypoderm of larvae Chironomus plumosus. Hence, these are also called "Salivary gland chromosomes." These are found in insects of the order Diptera and Collembola; in certain organs of mammals; and synergids, antipodes of flowering plants. Polytene chromosomes are also...
10.1K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

6.3K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
6.3K
Karyotyping01:17

Karyotyping

61.7K
Overview
61.7K
Chromosome Structure02:40

Chromosome Structure

22.9K
A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
22.9K
Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

23.4K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
23.4K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Perturbation of genes linked to common schizophrenia risk variants identifies cilia programs.

bioRxiv : the preprint server for biology·2026
Same author

R-loop landscapes in the developing human brain are linked to neural differentiation and cell type-specific transcription.

Translational psychiatry·2026
Same author

Downregulated transcription in chromosomal domains of midbrain dopamine neurons linked to schizophrenia.

Nature communications·2026
Same author

Repeat expansions in <i>C9orf72</i> rewire the 3D chromatin landscape in ALS.

bioRxiv : the preprint server for biology·2026
Same author

Functional implications of polygenic risk for schizophrenia in human neurons.

Nature communications·2026
Same author

3D genetic architecture of schizophrenia risk across three neuronal subtypes.

Molecular psychiatry·2025

関連する実験動画

Updated: Jul 17, 2025

Using Fluorescence In Situ Hybridization FISH to Monitor the State of Arm Cohesion in Prometaphase and Metaphase I Drosophila Oocytes
12:46

Using Fluorescence In Situ Hybridization FISH to Monitor the State of Arm Cohesion in Prometaphase and Metaphase I Drosophila Oocytes

Published on: December 6, 2017

11.5K

染色体接触は年齢とともに変化する

Schahram Akbarian1, Hyejung Won2

  • 1Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Science (New York, N.Y.)
|September 7, 2023
PubMed
まとめ

ゲノムの3次元構造は 生涯にわたって変化します このダイナミックな組織は 細胞機能と生物の発達に 影響を及ぼします

科学分野:

  • ゲノミクス
  • 細胞生物学
  • 発達生物学

背景:

  • 核内のゲノムの空間的配置は遺伝子調節に不可欠です.
  • ゲノム組織は静的ではなく,生物の寿命の間に大きな変化を遂げます.

研究 の 目的:

  • 3次元ゲノム組織の ダイナミックな改造を調査する
  • これらの変化が 細胞のプロセスにどのように影響するかを理解するためです

主な方法:

  • 先進的な染色体構成捕捉 (3C) 技術を活用する.
  • 大規模なゲノム相互作用データを分析するために計算生物学を使用する.

主要な成果:

  • クロマチンループとトポロジカルアソシエイトドメイン (TAD) の有意な変化が時間とともに観察された.
  • 特定のゲノム領域を特定し 顕著な改造を示した.

結論:

  • 3次元のゲノム構造は 非常に柔軟で 生命の過程で活発に再構成されます
  • これらのダイナミックな変化は 細胞の機能と適応に不可欠です

さらに関連する動画

Combining Magnetic Sorting of Mother Cells and Fluctuation Tests to Analyze Genome Instability During Mitotic Cell Aging in Saccharomyces cerevisiae
11:08

Combining Magnetic Sorting of Mother Cells and Fluctuation Tests to Analyze Genome Instability During Mitotic Cell Aging in Saccharomyces cerevisiae

Published on: October 16, 2014

12.6K
Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
22:27

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

409.1K

関連する実験動画

Last Updated: Jul 17, 2025

Using Fluorescence In Situ Hybridization FISH to Monitor the State of Arm Cohesion in Prometaphase and Metaphase I Drosophila Oocytes
12:46

Using Fluorescence In Situ Hybridization FISH to Monitor the State of Arm Cohesion in Prometaphase and Metaphase I Drosophila Oocytes

Published on: December 6, 2017

11.5K
Combining Magnetic Sorting of Mother Cells and Fluctuation Tests to Analyze Genome Instability During Mitotic Cell Aging in Saccharomyces cerevisiae
11:08

Combining Magnetic Sorting of Mother Cells and Fluctuation Tests to Analyze Genome Instability During Mitotic Cell Aging in Saccharomyces cerevisiae

Published on: October 16, 2014

12.6K
Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
22:27

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

409.1K