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Updated: Jul 17, 2025

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プロテオスタシスネットワークの調節は,腫瘍性KRAS阻害剤に対する腫瘍耐性を促進する

Xiangdong Lv1,2,3, Xuan Lu1,2,3, Jin Cao1,2,3

  • 1Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

Science (New York, N.Y.)
|September 7, 2023
PubMed
まとめ

腫瘍細胞は,プロテオスタシスを再プログラムすることで,KRAS阻害剤に対する抵抗性を形成する. イノシトールを必要とする酵素1α (IRE1α) の再活性化により,タンパク質のバランスが回復し,抵抗性が生じます.

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