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Updated: Jul 17, 2025

Mapping the Binding Site of an Aptamer on ATP Using MicroScale Thermophoresis
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クセノアプタマーと標的タンパク質における,水害性の非自然な塩基の厳密な相互作用

Michiko Kimoto1, Hui Pen Tan1, Ken-Ichiro Matsunaga1

  • 1Xenolis Pte. Ltd., 85 Science Park Drive, #02-05B, The Cavendish, Singapore 118259, Singapore.

Journal of the American Chemical Society
|September 7, 2023
PubMed
まとめ

研究者は,非自然基 (UB) を改変することによって,XenoAptamersを最適化しました. 新しい変種であるYsとBsは,標的タンパク質に対するXenoAptamer結合親和性を著しく強化し,特定の分子内相互作用を明らかにした.

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