関連する実験動画

Updated: Jul 17, 2025

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
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クリニカルおよび実験的な心不全におけるクローナル血液形成

Jesse D Cochran1,2, Yoshimitsu Yura1, Mark C Thel1

  • 1Robert M. Berne Cardiovascular Research Center, Division of Cardiovascular Medicine (J.D.C., Y.Y. [now with the Department of Cardiovascular Medicine, Nagoya University School of Medicine, Japan], M.C.T., H.D., A.H.P., Yuka Arai, Yohei Arai, K.H. [now with the Department of Internal Medicine II, Kansai Medical University, Osaka, Japan], E.P., N.W.C., A.K., M.E., M.H., K.K.H., H.S., Y.H.B., S.T., A.A., K.W.), University of Virginia School of Medicine, Charlottesville.

Circulation
|September 8, 2023
PubMed
まとめ

クローン造血 (CH) は,心臓機能の悪化と,保存されたエジェクション分数 (HFpEF) の心不全の予後に関連しています. TET2媒介のCHのマウスモデルでは,HFpEFの特徴が増加し,因果的な役割を示唆した.

キーワード:
バイオマーカークロナル血液形成心不全予後について

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