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Updated: Jul 17, 2025

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
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Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods

Published on: July 17, 2019

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ガン性RASを活性化するためのGAPのメカニズムベースの再設計

Dénes Berta1, Sascha Gehrke1, Kinga Nyíri2,3

  • 1Department of Physics and Astronomy, University College London, Gower Street, London WC1E 6BT, United Kingdom.

Journal of the American Chemical Society
|September 8, 2023
PubMed
まとめ

Ras GTPasesは細胞の信号伝達に 重要な役割を果たしますが 変異は癌を引き起こすのです この研究は,GTPの水解機構を明らかにし,腫瘍性Rasタンパク質の機能を回復する新しいRas- GAP変異体を設計した.

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