関連する実験動画

Updated: Jul 16, 2025

Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms
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Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms

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端末デオキシヌクレオチドリルトランスファーゼを使用して,結合情報を直接DNAでコードしたライブラリに記録する

Lukas A Schneider1, Basilius Sauter1, Koder Dagher1

  • 1Department of Chemistry, University of Basel, 4056 Basel, Switzerland.

Journal of the American Chemical Society
|September 13, 2023
PubMed
まとめ

末端デオキシヌクレオチチルトランスファーゼ (TdT) は,結合親和に比例するポリアデニン尾を生成することによって,DNAエンコードされたライブラリ (DEL) の結合物質の選択を可能にします. この方法は,広範な親和範囲の結合物質を効率的に識別し,DELスクリーニング能力を向上させます.

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