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資源が少ない環境で子供の成長が遅れる原因と結果
Andrew Mertens1, Jade Benjamin-Chung2,3,4, John M Colford2
1Division of Epidemiology and Biostatistics, University of California, Berkeley, Berkeley, CA, USA. amertens@berkeley.edu.
Nature
|September 13, 2023
まとめ
母親の健康と出産状態の改善は 子どもの成長障害を大幅に軽減します 早期の介入は不可欠です なぜなら男の子や 早期の欠陥を持つ人は より高いリスクと死亡率に直面するからです
科学分野:
- 小児科
- 世界保健
- 発達生物学
背景:
- 子供の成長が遅れたり 衰弱したりすると 短期的にも長期的にも 大きな健康リスクが生じます
- 現存する介入は,低所得国や中所得国における成長の鈍化という世界的な重荷に十分に対応していない.
- 効果的な予防戦略には,介入の重要な窓口を特定することが不可欠です.
研究 の 目的:
- 幼児の成長障害に対する人口介入の影響を分析する.
- 効果的な予防介入のための主要な曝露と年齢の窓を特定する.
- 成長経路に及ぼす母性や幼少期の要因の影響を理解する.
主な方法:
- 83,671人の子供と662,763人の測定を含む33人の縦断的なコホートにおける集団介入効果分析.
- 成長パラメータへの影響を評価するために30の個別の露出を分析した.
- 出生から2歳までの成長欠陥に関連する死亡率の調査.
主要な成果:
- 母親の人体測定と出生状態の改善により,長さ対年齢のzスコアは0. 40まで増加し,体重対長さのzスコアは24ヶ月で0. 15まで増加しました.
- 男の子は女児に比べて どの形態の成長障害も 高いリスクを示していた.
- 早期の産後成長障害は,その後の持続的な成長障害と死亡率の増加の強い予測因子であった (HR1. 98. 7).
結論:
- 産前要因や 幼少期の状態は 子供の成長の決定的な要因です
- 妊娠前期に重点を置くことは 新しい予防介入の重要な機会です
- 幼児死亡率を低減し,長期的な健康状態を改善するために,早期成長の欠陥をターゲットにすることが不可欠です.
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