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Updated: Jul 16, 2025

Imaging Spatial Reorganization of a MAPK Signaling Pathway Using the Tobacco Transient Expression System
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MKK6-p38α複合体の構造は,MAPKの特異性と活性化の基礎を定義する

Pauline Juyoux1, Ioannis Galdadas2,3, Dorothea Gobbo2,3

  • 1European Molecular Biology Laboratory (EMBL), Grenoble, France.

Science (New York, N.Y.)
|September 14, 2023
PubMed
まとめ

研究者は,MK6 (MAP2K) によってp38α (ミトゲン活性化タンパク質キナーゼ) の活性化をモデル化した. これは免疫シグナル伝達と 薬の開発に不可欠な ダイナミックで多段階のリン酸化メカニズムを示しています

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