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Updated: Apr 7, 2026

Targeted Antibody Blocking by a Dual-Functional Conjugate of Antigenic Peptide and Fc-III Mimetics DCAF
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Targeted Antibody Blocking by a Dual-Functional Conjugate of Antigenic Peptide and Fc-III Mimetics DCAF

Published on: September 17, 2019

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スプリット・アンド・ミックス・リポソーム・プロテオリシス・ターゲティング・キメラ・アプローチによる興味のあるタンパク質の分解

Chunli Song1, Zijun Jiao2,3, Zhanfeng Hou1

  • 1State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.

Journal of the American Chemical Society
|September 14, 2023
PubMed
まとめ

この研究では,リポソームベースの分割・混合型タンパク質分解ターゲティングキメラ (PROTAC) システムが導入されています. この新しいLipoSM- PROTACは,低濃度で腫瘍を標的とし,タンパク質を分解する効果を高めています.

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