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Updated: Jul 16, 2025

Gene Knock-in by CRISPR/Cas9 and Cell Sorting in Macrophage and T Cell Lines
11:32

Gene Knock-in by CRISPR/Cas9 and Cell Sorting in Macrophage and T Cell Lines

Published on: November 13, 2021

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耐久性の高い細胞治療をプログラムするための合成ノックイン配列のモジュラー・プールの発見

Franziska Blaeschke1, Yan Yi Chen1, Ryan Apathy1

  • 1Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

Cell
|September 15, 2023
PubMed
まとめ

新しいスクリーニングプラットフォームであるModPoKIは,T細胞治療を改善するための遺伝子改変の迅速な比較を可能にします. 癌に対するCAR-T細胞機能を強化する転写因子構造 (TFAP4) を特定した.

キーワード:
CRISPRについてキメリック抗原受容体慢性的な刺激人間のT細胞免疫療法ノックインズプールされたスクリーン合成表面受容体転写因子

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Generation of Knock-out Primary and Expanded Human NK Cells Using Cas9 Ribonucleoproteins07:20

Generation of Knock-out Primary and Expanded Human NK Cells Using Cas9 Ribonucleoproteins

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Efficient Generation of hiPSC Neural Lineage Specific Knockin Reporters Using the CRISPR/Cas9 and Cas9 Double Nickase System14:46

Efficient Generation of hiPSC Neural Lineage Specific Knockin Reporters Using the CRISPR/Cas9 and Cas9 Double Nickase System

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関連する概念動画

In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
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