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Updated: Jul 16, 2025

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
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Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

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SNRKによるアクトイン脱ポリメリゼーションによるDNA損傷および心筋縮における核形態学的変化

Paulina J Stanczyk1,2, Yuki Tatekoshi1, Jason S Shapiro1

  • 1Division of Cardiology, Department of Medicine, and Feinberg Cardiovascular and Renal Research Institute (P.J.S., Y.T., J.S.S., K.N., Y.C., Z.Z., A.D.J., A.M., A.A., H.-C.C., H.A.), Northwestern University School of Medicine, Chicago, IL.

Circulation
|September 18, 2023
PubMed
まとめ

SNF1関連キナーゼ (SNRK) は,Destrin (DSTN) と相互作用することで,心臓の大幅縮小およびDNA損傷を悪化させる. この相互作用はアクチンポリメリゼーションを妨害し,核異常と心筋細胞機能の障害を引き起こす.

キーワード:
AMP活性化タンパク質キナーゼデストリンアクチン左心室の縮筋細胞,心臓

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Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
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Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Rheumatic Heart Disease I: Introduction

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