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Updated: Jul 16, 2025

Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides
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Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides

Published on: July 14, 2015

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多銅クラスターは,ペプチドの酸化フェノールマクロサイクリング (OxPM) を可能にします

Anna Libman1, Mor Ben-Lulu1, Eden Gaster1

  • 1Department of Chemistry, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.

Journal of the American Chemical Society
|September 18, 2023
PubMed
まとめ

研究者は,バンコミシンリングモデルを含む複雑なマクロサイクルペプチドを合成するために,マルチコッパー (II) クラスターを使用した新しいバイオミメティック方法を開発した. この効率的なアプローチは 抗生物質の重要な構造を作る上で 課題を克服します

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Ring-opening metathesis polymerization or ROMP involves strained cycloalkenes as starting materials. The mechanism of ROMP proceeds by reacting cycloalkene with Grubbs catalyst to give metallacyclobutane intermediate which undergoes a ring-opening reaction to form new carbene. The new carbene reacts with another molecule of cycloalkene. Repetition of these steps leads to the formation of an unsaturated open-chain polymer product. All these steps are reversible, however, relieving the ring...
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Epoxidation of alkenes via oxidation with peroxy acids involves the conversion of a carbon–carbon double bond to an epoxide using the oxidizing agent meta-chloroperoxybenzoic acid, commonly known as MCPBA. Since the O–O bond of peroxy acids is very weak, the addition of electrophilic oxygen of...
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Recently, the development of olefin metathesis polymerization advanced the field of polymer synthesis. Simply put, the reorganization of substituents on their double bonds between two olefins in the presence of a catalyst is known as the olefin metathesis reaction. The use of metathesis reaction for polymer synthesis is called olefin metathesis polymerization.
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