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還元性カルボキシル化がT細胞の分化に表遺伝的に指示する

Alison Jaccard1,2, Tania Wyss1,3, Noelia Maldonado-Pérez4

  • 1Department of Oncology, University of Lausanne, Lausanne, Switzerland.

Nature
|September 21, 2023
PubMed
まとめ

CD8+ T細胞の特定の代謝経路を阻害すると,記憶細胞の形成が促進されます. この代謝再配線は,がんに対するキメリック抗原受容体 (CAR) T細胞治療の有効性を高めます.

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