関連する実験動画

Updated: Jul 15, 2025

Bacterial Inner-membrane Display for Screening a Library of Antibody Fragments
12:28

Bacterial Inner-membrane Display for Screening a Library of Antibody Fragments

Published on: October 15, 2016

11.6K

オートファジー受容体インスピレーションによる抗体融合タンパク質

Ziwen Jiang, Yu-Hsuan Kuo, Michelle R Arkin

    Journal of the American Chemical Society
    |September 25, 2023
    PubMed
    まとめ

    研究者らは,望ましくないタンパク質集積物と臓器を分解するために,新型のオートファギー受容体インスパイアされたターゲティングキメラ (AceTAC) を開発した. この画期的な発見は 細胞内分解を標的とし 老化や神経変性疾患に 潜在的に影響を与える新しい方法を提供します

    さらに関連する動画

    High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines05:33

    High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

    Published on: November 9, 2020

    9.7K
    Analysis of Endocytic Uptake and Retrograde Transport to the Trans-Golgi Network Using Functionalized Nanobodies in Cultured Cells11:05

    Analysis of Endocytic Uptake and Retrograde Transport to the Trans-Golgi Network Using Functionalized Nanobodies in Cultured Cells

    Published on: February 21, 2019

    9.1K

    関連する概念動画

    Autophagic Cell Death01:18

    Autophagic Cell Death

    Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
    Autophagy and Apoptosis
    Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
    3.4K
    Autophagy01:27

    Autophagy

    Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
    An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
    4.3K
    Regulated Protein Degradation02:58

    Regulated Protein Degradation

    It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
    Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
    7.4K
    Delivery Pathways to the Lysosome01:36

    Delivery Pathways to the Lysosome

    Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
    Endocytosis
    In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
    6.6K
    Phagocytosis of Apoptotic Cells01:17

    Phagocytosis of Apoptotic Cells

    Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
    Normal cells contain receptors that prevent them from being recognized...
    3.9K
    Receptor Downregulation in MVBs01:15

    Receptor Downregulation in MVBs

    Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
    The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
    2.1K