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Electrophysiology of Normal Cardiac Rhythm01:19

Electrophysiology of Normal Cardiac Rhythm

5.6K
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
5.6K
Correlation between ECG and Cardiac Cycle01:25

Correlation between ECG and Cardiac Cycle

6.4K
The electrical signals recorded on an electrocardiogram (ECG) occur before the mechanical processes of contraction and relaxation during the cardiac cycle.
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
6.4K
Cardiac Action Potential01:30

Cardiac Action Potential

1.6K
Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
1.6K
Disturbances in Heart Rhythm01:28

Disturbances in Heart Rhythm

997
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
997
The Cardiac Cycle01:13

The Cardiac Cycle

88.7K
The heart beats rhythmically in a sequence called the cardiac cycle—a rapid coordination of contraction (systole) and relaxation (diastole).
The Process
Electrical signals—sent from the sinoatrial (SA) node in the right atrial wall to the atrioventricular (AV) node between the right atrium and right ventricle—cause both atria to simultaneously contract. When the signal reaches the AV node, it pauses for approximately a tenth of a second, allowing the atria to contract and...
88.7K
Electrocardiogram Fundamentals01:28

Electrocardiogram Fundamentals

627
Introduction
An electrocardiogram (ECG) is a diagnostic tool for identifying cardiac conditions such as arrhythmias, conduction abnormalities, and myocardial ischemia.
Definition
An electrocardiogram (ECG) visualizes the heart's electrical activity by tracing the electrical movement associated with each heartbeat on a graph or monitor. As the heart beats, an electrical wave passes through it, correlating with the cardiac cycle events.
Parts of an ECG
An ECG utilizes electrodes on the skin...
627

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Noninvasive Electrocardiography in the Perinatal Mouse
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脊椎動物の心臓の動脈に 生物電気的相変化が起きました

Bill Z Jia1,2,3, Yitong Qi1, J David Wong-Campos1

  • 1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.

Nature
|September 27, 2023
PubMed
まとめ

最初のゼブラフィッシュの心臓の鼓動は 不規則なタイミングで 変化する場所から突然現れるのです 個々の細胞の電気的性質の 漸進的な発達により 組織規模で 協調した 強力な拍子が生じます

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Optocardiography and Electrophysiology Studies of Ex Vivo Langendorff-perfused Hearts
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科学分野:

  • 発達生物学
  • 心血管の生理学
  • バイオ物理学

背景:

  • 定期的な心拍は脊椎動物の生存に不可欠で 通常は成熟した心臓の ローカルなペースメーカーによって動きます
  • 初期の胎児の心臓では,ペースメーカーは広く分布しており,組織規模の活動の確立と維持について疑問を投げかけています.
  • 静かな心臓から鼓動する心臓への最初の移行と初期の鼓動の空間時間的動態は十分に理解されていません.

研究 の 目的:

  • ゼブラフィッシュの胚の 最初の心臓の鼓動を 個々の電気的な出来事のスケールで特徴づけること
  • 初期心拍の周囲の心臓の興奮と伝導の発達を分析する.
  • 単細胞の非同期的な発達が 組織規模での協調的な心臓活動につながることを理解する.

主な方法:

  • ゼブラフィッシュの胚の 初期の心臓の電気活動を捉えるために 全光電気生理学を使用しました
  • 初期の心拍の空間と時間の動態と その後の発展を分析した
  • 生物電気的動力学をモデル化しました 不変の円のバイフォーケーションフレームワークのノードを使ってです

主要な成果:

  • 最初の数回の心拍は 不規則な間隔で突然現れた.
  • 原始的な心臓全体で 電気活動の一貫した伝播が観察されました
  • ペースメーカーの開始部位は 個々の胚と時間によって異なる.
  • アクションポテンシャルアップストロークは,CaV1.2チャネルによって引き起こされる.

結論:

  • 静止状態から 協調的な打撃への移行は 組織規模の現象です
  • この移行は,単細胞生物電気的性質の漸進的かつ非同期的な発展から生じる.
  • この研究は,初期の心臓の電気生理学と伝導ダイナミクスの詳細な特徴を提供します.