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Updated: May 12, 2026

DNA Methylation: Bisulphite Modification and Analysis
12:34

DNA Methylation: Bisulphite Modification and Analysis

Published on: October 21, 2011

105.0K

メチル化ヌクレオチドベースのタンパク質分解標的キメラは,メチル-CpG結合タンパク質2の標的分解を可能にします

Zhen Wang1, Jing Liu1, Xing Qiu2

  • 1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, United States.

Journal of the American Chemical Society
|September 29, 2023
PubMed
まとめ

研究者はメチルタンパク質分解を標的とするキメラ (メチル-PROTACs) を開発し,がん細胞のメチル-CpG結合タンパク質2 (MeCP2) を分解し,エピジェネティックターゲットの新たな治療戦略を提供した.

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High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines05:33

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