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Updated: Jul 15, 2025

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
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Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine

Published on: February 16, 2018

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薬剤設計におけるバイオカタリシス:エンジニアリングされた還元性アミナゼ (RedAms) は,複数のステレオセンターを持つキラルビルディングブロックにアクセスするために使用されます

Arnau Rué Casamajo1, Yuqi Yu1, Christian Schnepel2

  • 1Department of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester M1 7DN, United Kingdom.

Journal of the American Chemical Society
|October 2, 2023
PubMed
まとめ

エンジニアリングされた還元性アミナーゼ (RedAm) を使用した新しい生物触媒プロセスは,薬剤発見のための特定のキラルアミンの構成要素を提供します. この方法は,新しい治療薬の開発に不可欠な,望ましい同位体を生成します.

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