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Updated: Jul 15, 2025

Quantitative Analysis of Chromatin Proteomes in Disease
08:11

Quantitative Analysis of Chromatin Proteomes in Disease

Published on: December 28, 2012

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遺伝学と疾患関連による大規模プラズマタンパク質の比較

Grimur Hjorleifsson Eldjarn1, Egil Ferkingstad1, Sigrun H Lund1,2

  • 1deCODE Genetics/Amgen, Reykjavik, Iceland.

Nature
|October 4, 2023
PubMed
まとめ

オリンクやソマスキャンのような 高度なプロテオミクスプラットフォームは タンパク質と遺伝子を結びつけることで 病気の洞察力を提供します 両方のプラットフォームでは同様の数の遺伝的関連が検出されるが,Olinkはより高い検査検証率を示し,疾患研究のプラットフォームの違いを強調している.

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Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
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