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Updated: Jul 15, 2025

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
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Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting

Published on: March 1, 2019

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シアログリカン結合はヒトのコロナウイルスの発症を誘発する

Matti F Pronker1, Robert Creutznacher2, Ieva Drulyte3

  • 1Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, Utrecht, The Netherlands.

Nature
|October 4, 2023
PubMed
まとめ

人間のコロナウイルスのHKU1スパイクタンパク質は,シアログリカン受容体と結合すると,開かれた状態に移行する. この形状の変化は,アロステリッククロスストークによって引き起こされ,免疫逃避と二重受容体の使用を容易にする可能性があります.

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