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Updated: Jul 14, 2025

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16
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アルファウイルス受容体MXRA8の脊椎動物特有の結合モード

Ofer Zimmerman1, Maxwell I Zimmerman2, Saravanan Raju2

  • 1Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.

Cell
|October 7, 2023
PubMed
まとめ

哺乳類のMXRA8とは異なり,鳥類のMXRA8はSindbisやWEEVのようなアルファウイルスに結合する. 新しいキメリック受容体は様々なアルファウイルス感染を中和し,幅広いスペクトルの阻害剤への道を開きます.

キーワード:
アルファウイルス鳥たちクリオ電子顕微鏡進化について阻害剤哺乳類病原性レセプター種について構造トロピズム

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