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単細胞内の熱異質性を探査する熱電気ナノ流体学

Hao Ding1, Kang Liu1, Xinlu Zhao1

  • 1State Key Laboratory of Analytical Chemistry for Life Science, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, Jiangsu, China.

Journal of the American Chemical Society
|October 9, 2023
PubMed
まとめ

新しいナノピペット電気温度計 (NET) は,高感度で細胞内温度をリアルタイムで測定できます. この画期的なツールは 免疫療法中の癌細胞の熱的異質性を明らかにし 温度と治療抵抗性を関連付けています

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関連する概念動画

Specific Heat01:16

Specific Heat

The specific heat capacity of a substance refers to the energy required to increase the temperature of one gram of that substance by one degree Celcius. Specific heat capacity is often represented in calories (cal), grams (g), and degrees Celsius (oC), but can also be expressed in joules (J), kilograms (kg), and Kelvin (K), among other units.
For example, increasing the temperature of one gram of water by 1°C requires one calorie of heat energy and can be written as 1 cal/g-°C, or 4186 J/kg/K.
Atomic Nuclei: Nuclear Spin State Population Distribution01:14

Atomic Nuclei: Nuclear Spin State Population Distribution

Near absolute zero temperatures, in the presence of a magnetic field, the majority of nuclei prefer the lower energy spin-up state to the higher energy spin-down state. As temperatures increase, the energy from thermal collisions distributes the spins more equally between the two states. The Boltzmann distribution equation gives the ratio of the number of spins predicted in the spin −½ (N−) and spin +½ (N+) states.
Heat Flow and Specific Heat01:12

Heat Flow and Specific Heat

Heat is a type of energy transfer that is caused by a temperature difference, and it can change the temperature of an object. Since heat is a form of energy, its SI unit is the joule (J). Another common unit of energy often used for heat is the calorie (cal), which is defined as the energy needed to change the temperature of 1 g of water by 1 °C, specifically between 14.5 °C and 15.5 °C, since the energy needed shows a slight temperature dependence. Another commonly used unit is the kilocalorie...